The T104A/T150A double mutant was no more resistant to inactivation than the T150A single mutant (Fig. of M-phase entry. These results also show that multisite phosphorylation cooperatively inactivates Wee1A and cooperatively promotes Wee1A proteolysis. Wee1 was first identified through genetic studies of cell size control and cell cycle progression in (30, 31, 38). Subsequent work … Continue reading The T104A/T150A double mutant was no more resistant to inactivation than the T150A single mutant (Fig